Synthesis molecular modeling and anticonvulsant activity of some hydrazone, semicarbazone, and thiosemicarbazone derivatives of benzylidene camphor

Saurabh Agrawal,¹ Jainendra Jain,² Ankit Kumar,³ Pratibha Gupta,⁴ Vikas Garg<sup>5

1</sup>Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India; ²Ram–Eesh Institute of Vocational and Technical Education, Greater Noida, Uttar Pradesh, India; ³Kharvel Subharti College of Pharmacy, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India; ⁴Atarra Degree College, Atarra, Banda, India; ⁵Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India

Abstract: Four series of 20 novel derivatives of benzylidene camphor with hydrazones, semicarbazones, and thiosemicarbazones were designed and synthesized. The newly synthesized compounds were evaluated for their anticonvulsant activity by maximal electroshock seizure model. Compounds showed varying degrees of anticonvulsant activity, most marked effect was observed for compounds 2f and 4d with lesser neurotoxicity. Molecular docking studies of most active compounds (2f and 4d) of the series revealed that they interact with LYS329A, GLN 301A, and THR 353B residues of 1OHV protein via hydrogen bonding and Pi interaction.

Keywords: camphor, semicarbazone, hydrazone, thiosemicarbazone, anticonvulsant